- "I told them not to eat the infected... then they started changing. They changed sensitive to bright lights, to shining my flashlight would send them into a violent rage! I've disabled the elevator to trap them down there. God rest their souls."
- —Sam Ackerman
As Feeders are auditory-based Necromorph forms, they rely primarily on sound. Walking slowly and at a distance will prevent the player from getting harmed by them. Alternatively, throwing objects around the Feeders with Kinesis will temporarily distract the Feeders from the player. Similarly, do not shine the weapon's flashlight on them as it would definitely attract them to the player. So it is best advised while low on ammo to stick to a wall and try and slip past them. However, trying to locate them would be difficult as in low light areas, shining a flashlight would reveal your position. This can be countered by throwing around objects before entering a dark room. It is also advised to take care of a Feeder quickly as when alerted it has the ability to call in more of the pack.
Naturally weak and docile, Feeders cannot withstand much punishment from Isaac, dying within two hits from a melee strike. However once alerted or if a quarantine lockdown is in effect, they will swarm in gigantic numbers, potentially overwhelming players within seconds if they are caught in a chokepoint. Enhanced forms of Feeders can be killed with a single shot to the head, though it takes several body and limb shots to kill them otherwise.
- If the player succeeds in the quick time event, Isaac/Carver will grab the Feeder on his back and throw it onto the ground, before killing it by stomping its head in.
- However, if the player fails, the Feeder will jump off his back before quickly approaching, jaw stretching wide open. It bites onto Isaac's/Carver's face, before pulling his head off, resulting in decapitation.