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Events leading up to Dead Space 2 suggest that the hospital's patients and staff may been experiencing Marker related symptoms before the outbreak. Hospital personnel experienced an spike in anxiety or psychological issues that was considered unusual as well To compound the situation further, the added element of undisclosed medical experiments performed on the psych patients by EarthGov for Project Telomere, reveals they became combative, frightened and agitated from memory loss caused by a drug..
Outbreak on the SprawlEdit
Titan Memorial is overrun by Necromorphs by the initial start of Dead Space 2. The telltale signs of chaos and death are written across the walls and general environment of the hospital; incomplete surgeries, bodies hanging limp in wheel chairs and patients left in their beds to die; all suggest the hospital staff were overtaxed by infected and living civilians looking to the hospital for help during the evacuation ordered by Director Hans Tiedemann. When the events of Dead Space: Ignition come to an end, Franco Delille enters an already ruined psych ward to extract Isaac Clarke for the Church of Unitology.
His mission is only partially successful; Isaac is freed from the confinement of his Stasis, but is left to escape the hospital on his own after Delille is killed by an Infector. Sprawl Security roamed the halls, on the look out for the "key subjects" Tiedemann wants eliminated; they are systematically picked off by the Necromorph inhabiting the hospital. Foster Edgars is the only hospital staff encountered physically unscathed by the incident before he commits suicide in front of Isaac. Aside from himself, Nolan Stross and Lexine Weller resided inside the hospital before and during the outbreak. Lexine was in the middle of a fertility examination when her husband, Gabe, warned her of the danger and urged her to escape. By virtue of the chaos, Stross may have been allowed to escape his cell.
Stross was able to escape the lockdown while Isaac was forced to find another route out of the complex. Lexine remained hidden in the psych ward, hiding from the Oracles and Victor Bartlett, waiting for the arrival of Gabe. Gabe seems to arrive at the hospital only moments after Isaac has killed a Tripod and headed for Titan Heights. The state of the hospital has worsened by the time Weller enters; the Corruption and number of Necromorphs (enhanced and standard) spreading at an incredible rate. With the sacrifice of his life, Lexine is able to escape the hospital and Titan Station in a gunship.
Like the other environments on the Sprawl, the hospital is destroyed when the station exploded.
- Many of Dead Space 2's Conduit rooms are opened and accessible in Dead Space 2: Severed; containing Stores and Benches. The Power Nodes Isaac can access in the original game are also accessible in Severed in their original locations.