Isaac Clarke's mother and was married to Poul Clarke. Not much was known about Octavia, but it was revealed in special text logs obtained after the game that she suffered from depression during her husband´s extended missions. She was encouraged by her psychiatrists to find something meaningful to do, eventually finding solace in the Church of Unitology. She became highly devout in the religion, going so far as to sell all of her assets to the Church of Unitology. This decision would negatively affect her son, Isaac who would be forced to forego admission to a prominent engineering college due to lack of finances and go to a lesser college. This also made him hate and distrust Unitologists and Unitology in general. Her fate was unknown.
- Like her husband and son, the name Octavia Clarke references two revered science fiction writers: Octavia Butler and Arthur C. Clarke.