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Massive Necromorphs that are able to broadcast the Marker Signal from the Moons to smaller Necromorph variants are called "Hive Minds".
Only two hive mind variants are seen in the series, the first one being the Aegis VII Hive Mind which is composed of humans and the second one being the Nexus on Tau Volantis, that are made from the extinct alien lifeforms.
Based on the provided biomass, the appearance of the hive mind varies. The outcome may be completely different to the anatomy of the original host(s) or is very similar to the host. The Aegis VII Hive Mind, which is based on humans, resembles a worm-like creature with a round mouth filled with long flytrap-like teeth. The head is rounded with "eyes" made from sacks containing yellow liquid. It has a rib cage filled with sacks made from the same material as the "eyes", possibly serving as its heart. The beast will die if these are destroyed, so the rib cage serves as the only line of defense for the heart.
The Nexus is completely different as opposed to the Aegis VII Hive Mind. Like the first one, it resembles an insect, although this one does more than the Hive Mind. It has four blades and mantis-like feet used in traveling. The head is of the original host's with few modifications as opposed to the Aegis VII Hive Mind with sacks containing yellow liquid serving as weak points, like the Aegis VII Hive Mind. It also has a large sack serving as its heart, although the creature won't die if it is destroyed, unlike the other variant. It also has a digestive system, a stomach containing three nests (if these are killed along with the other outside weak spots, the creatures dies) and a chamber located in its belly containing nerve clusters, that receive signals.
No matter of these differences, all variants have weak spots made from sacks filled with the yellow liquid that are weak and vulnerable to damage. The sacks serve their own purposes depending on what the Necromorph is like. However, all hive minds have antenna-like appendages on their backs. The purpose of these is unknown but they could serve as antennas helping in broadcasting the Marker Signal to other beings as well as forwarding commands to the other Necromorphs.