Shooting them in the body didn't seem to work. Go for the limbs, dismember them. That should do the job.
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Following the tram derailment, Daina reroutes Isaac through a mall called The Concourse where he has his first encounter with The Pack. After entering the waste management area, Isaac manipulates the Garbage Compactor while in Zero-G, gaining entrance to the Cassini Towers. After traversing the area, he eventually reaches the Sprawl's Church of Unitology.