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When an immense mining ship, the USG Ishimura, comes into contact with a mysterious alien artifact in a remote star system, its communications with Earth are mysteriously cut off. Engineer Isaac Clarke is sent to repair the Ishimuras communications array, but he arrives to find a living nightmare—the ship is a floating bloodbath, the crew unspeakably mutilated and infected by an ancient alien scourge. Clarkes repair mission becomes one of survival as he fights not just to save himself, but to return the artifact to the planet at any cost.