Dead Space

Chapter 12: Autopsy

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Game: Dead Space 3
Previous Chapter: Signal Hunting
Next Chapter: Reach for the Sky
Ishimura Dead Space Wiki has a walkthrough guide to this level, Chapter 12: Autopsy. See Chapter 12: Autopsy/Walkthrough.

'Autopsy' is the twelfth chapter of Dead Space 3.


Isaac has collected the Nexus probe parts. Now, he must venture deep inside the creature’s enormous, frozen corpse to stimulate its dormant neural pathways. Santos believes that doing this will reveal a signal that points to the Machine’s location


Nexus-03 Site Edit

Once we are back at the observation platform you will notice that there are two lifts opposite Santos’s position and two long walkways to the left and the right leading to platforms to either side of the Nexus in the centre of the room. We need to make our way to the end of each walkway, activate the terminal here and then use kinesis on the crank.

Once both harpoons have been activated, return to Santos and enter the cage here. Ride it over and down into the next area.

We’ll be inside the giant necromorph! To proceed through this region, you need to pull out your probe gun and aim it. It will start beeping. Follow the beeps until they get closer and closer together. At this point shoot the yellow sack hanging from the roof that the probe is indicating as the target.

You will need to shoot three of these nerve endings and after the first and third time that you do, a swarm of feeders will spawn and attack you. These are a more advanced version of the original feeders, appear as black in color and take twice the amount of damage. Each wave consists of around 10-12 of these ‘super’ feeders, so prepare yourself!

The nerve endings can be found at the following locations:

  1. After getting off the lift, turn right and go down the passage a short distance, it is on the roof here. Once you shoot it prepare for ‘super’ feeder inundation!
  2. From the lift, move a short distance down the left passage and look up to the left at the turn in the passageway.
  3. Follow the left tunnel from nerve ending number 2 until it exits into a larger room; shoot any one of the nerve clusters that you find in here. Once you have shot this, be prepared for another ‘super’ feeder attack.

Once you have knocked off the three clusters and have survived the waves of super feeders, return to the lift for a short scene.

Afterwards, use kinesis on the control to open the door and proceed through the door to the elevator on the left. After getting off, continue along the walkway to the left and make your way through the doors to the furnace room again. Here you will notice that another door is now unlocked. Move on through here.

As you enter, destroy the crates to the right (note there is also an upgrade circuit here on new game +) if you need some ammo or reagents and proceed through the room to the left until you reach the next open door. There is a bench next to the exit if you require its services. Exit through the door for a scene.

Cliffs of Volantis Edit

When you regain control, move up to the cover in front and kill the Unitology commandos as they unload from the drop ship. After a few short moments a scene will play and we’ll meet another type of necromorph – the Nexus.

New Enemy: The Nexus
The Nexus is a massive necromorph form that will remain stationary during the fight. It will hang over the cliff whilst it faces you. The nexus has a pair of massive claws that it will bring down in a bid to crush Isaac, simply dodge to the side to avoid these. The nexus will also fire off small red projectiles that will land on the ground and pulsate, if you do not destroy these, they will hatch into feeders. After shooting the red eggs, the nexus will sit still for a few moments with its pulsating yellow heart exposed. Try to get as many shots as you can in on it.

After taking damage, the nexus’s head will come down to Isaac’s level and it will start to suck you into its mouth. To prevent this from happening, shoot the glowing bulbs around its mouth.

As mentioned above, the tactics for defeating the nexus are simple: Avoid the necromorphs talons, shoot as many of the eggs as you can and then shoot the nexus in the heart until it collapses forward. Shoot its mouth until it stops sucking and repeat! Eventually, once you have destroyed all of the mouth tentacles, you will not be able to stop it from sucking you in.

Nexus Interior Edit

After a scene you will regain control in a zero gravity environment and subsequently meet a new enemy- the hive mind.

New Enemy: The Nexus
The Nexus is wall mounted enemie that feature three prominent tentacles. They fire off groups of small, red projectiles that will home in on Isaac and deal a fair bit of damage if they manage to hit him. During a fight with hive minds, you need to shoot or boost out of the way of the projectiles, whilst still trying to sever the hive mind’s tentacles when you get the opportunity.  These necromorph growths are quite weak on their own, but the heat-seeking shots make them a little tricky.

There are three hive minds in this area. We need to try and focus on one at a time and sever their tentacles to kill them. Additionally we need to keep an eye out on the other two at the same time in order to avoid or shoot down any incoming attacks. Once you have killed all three hive minds a scene will play.

During the scene, hit the button prompt that appears.

Note: For defeating the The Nexus you will earn the Achievement/Trophy ‘Intestinal fortitude’.

Continue up the nearby slope to continue onto the next chapter.


In order of appearance:


  • Regardless of what weapons the player is carrying at the time, Isaac will shoot Norton using a submachine gun.


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